HitS in WuXi AppTec
Locations
Our Team
Management Team |
Xuanjia Peng Ph.D.
Vice President
Head of HitS 14+ yrs experience on Med-Chem at WuXi AppTec
Experienced in chemistry and drug discovery |
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Letian Kuai Ph.D.
Exec. Dir.
Head of Strategy & Technology CSO of Crelux 10+ yrs experience on DEL at GSK
Experienced in biology, informatics and drug discovery |
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Gundel Hager, Ph.D.
Managing Director of Crelux
20+ yrs Drug Development
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Project Management and Client Relationship |
Dr. Thomas Waldmann
Head of Customer Relationship
3+ yrs Crelux GmbH
15+ yrs experience in technical and commercial client support 12+ yrs experience in protein science, assay & technology development |
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Dr. Michael Raba
Program Director Crelux
4+ yrs Crelux GmbH
14+ yrs experience in biophysical membrane protein characterization 3+ yrs experience in managing integrated drug discovery projects |
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Dr. Nuska Tschammer
Subject Matter Expert
15+ yrs experience in integrated early drug discovery processes, biophysics, molecular pharmacology, medicinal chemistry, innovation
20+ yrs experience in chemistry, biology, public relations and training |
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Dr. Wenting Chen
Head of Project Management
5+ yrs WuXi AppTec
3+ yrs experience on DEL and project management |
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Dr. rer. nat. Christina Daschkin-Steinborn
Head of Project Management Crelux
2+ yrs at Crelux GmbH
8+ yrs scientific project management 8+ yrs anti-infective and anti-microbial development 10+ yrs biochemistry and molecular biology |
Science Team| Protein Production | |
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Dr. Thomas Meins
Head Dept. Protein Production
10+ yrs Crelux GmbH
2 yrs Sanofi R&D, France 20+ yrs drug target prod. Recognized Expert for Membrane Proteins, Protein complexes, Iso-tope labelled Proteins. |
| FBDD & Biophysics | |
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Dr. Moran Jerabek-Willemsen
Head of Biophysics & Screening
3+yrs Crelux GmbH
10+yrs NanoTemper Technologies 20+yrs developing MicroScale Thermophoresis and nanoDSF technologies |
| Crystallography | |
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Dr. Ingo Korndoerfer
Head of Crystallography
12+ years Crelux GmbH
19+ leading protein crystallography teams and facilities 30+ years experiences in protein crystallography |
| DEL | |||||
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Dr. Alex Satz
Senior Dir.
Strategy & Operations
14+ years of experience on DEL, prior experience at Roche, GSK, Praecis, AstraZeneca
20+ years of experience in organic chemistry, medicinal chemistry |
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Dr. Wenji Su
Assistant Dir.
Head of China R&D
3+ years of experience on DEL, prior experience at GSK
10+ years of experience on biochemistry, cell and molecular biology |
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Dr. Hongfang Yang
Senior Dir.
10+ years of experience on DEL, prior experience at GSK, Organix
20+ years of experience in organic chemistry |
| Antibody | |
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Dr. Peng Wang
Senior Dir.
Head of Antibody
6+ yrs experience on Antibody at WuXi AppTec
2+ yrs experience on Antibody at Roche 1 yr experience on Cell biology at Crownbio |
Technical team
Equipment
Library Production
Library Production
Analytical
( Reaction Dev., BB validation,
library production, digestion )
( Reaction Dev., BB validation,
library production, digestion )
Preparative Separation
Tecan
Route exploration :10-15 / Month
Library production :10+ / Month
Product supply : 0.5~50 μmol / library
Library production :10+ / Month
Product supply : 0.5~50 μmol / library
UHPLC-LTQ
BB validation: 10,000+ / Week
New method: 50+ in total
Five LTQs in our lab
New method: 50+ in total
Five LTQs in our lab
UHPLC-TOF
Better resolution,
it can be accurate to four decimal places
it can be accurate to four decimal places
Prep. HPLC
Scale between
10 nmol ~ 10 μmol
10 nmol ~ 10 μmol
Affinity Selection
Automated
Affinity Selection
Affinity Selection
KingFisher Flex
Consistent fluidics, precise liquid handling
Accurate
Quantitation
Quantitation
QuantStudio 7 Flex
Quality control at protein & nucleotide level; before, during, and after the selection
Integrated
Sequencing
Sequencing
illumina HiSeq X
DEL-specific workflow for enhanced accuracy and throughput
Additional
Capabilities
Capabilities
BD Aria III
Cell-based selection for expanded target classes
