Organic Letters: WuXi AppTec Developed Novel Photoredox-Mediated Decarboxylative Coupling between α‑Amino Acids and DNA-Conjugated Carbonyls

#OrganicLetters: WuXi AppTec Developed Novel Photoredox-Mediated Decarboxylative Coupling between α‑Amino Acids and DNA-Conjugated Carbonyls

This work has been published on Organic Letters as the #cover #article. And this reaction enjoys huge potential and broad prospect in the DNA-encoded library production.

Recently, WuXi AppTec HitS Unit has reported a DNA-compatible photoredox decarboxylative coupling reaction between α-amino acids and carbonyl compounds for the efficient synthesis of DNA-conjugated sp3-rich 1,2-amino alcohols. The reaction proceeds efficiently for a wide range of DNA-conjugated aldehydes and ketones under mild conditions, and provides the desired 1,2-amino alcohols with high conversions, enjoys huge potential and broad prospect in the DNA-encoded library production. Also, qPCR and sequencing data analysis indicates no significant DNA damage upon photoredox decarboxylative coupling reaction.

Reference:
Wen, Huanan; Ge, Rui; Qu, Yi; Sun, Jialin; Shi, Xiaodong; Cui, Weiren; Yan, Hao; Zhang, Qi; An, Yulong; Su, Wenji; Yang, Hongfang; Kuai, Letian; Satz, Alexander. L.; Peng, Xuanjia. Org. Lett. 2020, 22(24), 9484-9489. DOI:10.1021/acs.orglett.0c03461 #DEL #PhotoredoxMediated

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